解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::This experiment was conducted to investigate the effects of a benzylideneacetophenone derivative ((2E)-3-(4-hydroxy-3-methoxyphenyl)phenylpro-2-en-l-one (JC3)) on trimellitic anhydride (TMA)-induced atopic dermatitis (AD)-like symptoms in mice. To induce AD, the dorsal skins of mice were treated with 5% TMA on day 0 a...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-019-00971-w
更新日期:2019-06-01 00:00:00
abstract::Ziprasidone (ZIP) is an effective antipsychotic with low side effects than other second-generation antipsychotics. Despite this, there are reports of adverse events and previous studies associating the use of ZIP the inflammatory response. It is possible to infer that bioactive molecules present in some foods could at...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-018-0946-9
更新日期:2019-06-01 00:00:00
abstract::Studies have shown that apolipoprotein M (apoM), the main carrier of sphingosine-1-phosphate (S1P), is closely related to lipid metabolism and inflammation. While there are many studies on apoM and lipid metabolism, little is known about the role of apoM in inflammation. Atherosclerosis is a chronic inflammatory proce...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-018-0918-0
更新日期:2019-04-01 00:00:00
abstract::Most cases of posttraumatic ankle osteoarthritis (PTAOA) represent a sequela of ankle fractures. The cytoplasmic polyadenylation element-binding protein 1 (CPEB1) is an RNA binding protein that controls protein expression. Here, we report the previously unappreciated association of CPEB1 with PTAOA. We found that CPEB...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-018-0920-6
更新日期:2019-04-01 00:00:00
abstract::CD4+ T cell subset imbalance plays an important role in the development of diabetic complications. Neutrophils have recently been known as the regulator of CD4+ T cell differentiation. However, whether neutrophils affect CD4+ T cell population in diabetes is still elusive. In this study, we investigated the effect of ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-018-0913-5
更新日期:2019-04-01 00:00:00
abstract::TanshinoneIIA (TanIIA) has been demonstrated to possess numerous biological effects. However, the specific effect of TanIIA on macrophage polarization has not been reported. In this study, it was revealed that TanIIA might play a pivotal role in macrophage polarization. As our results indicated, cell morphology was ch...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-018-0891-7
更新日期:2019-02-01 00:00:00
abstract::Sepsis is a systemic inflammatory response syndrome caused by infection. The core mechanism underlying sepsis is immune dysfunction, with macrophages, as important cells of the innate immune system, playing an essential role. Autophagy has been shown to be closely related to inflammation and immunity, and autophagy en...
journal_title:Inflammation
pub_type: 杂志文章,评审
doi:10.1007/s10753-018-0890-8
更新日期:2019-02-01 00:00:00
abstract::IL-17-producing Th17 cells and IFN-γ and IL-17 double-producing Th1/17 cells have been identified as the pathogenic cells in inflammatory bowel disease (IBD). Retinoic acid-related orphan receptor γt (RORγt) is a master regulator for the differentiation and activation of Th17 and Th1/17 cells. We discovered a novel or...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-018-0875-7
更新日期:2019-02-01 00:00:00
abstract::In this study, we aimed to investigate the effect of electro-acupuncture (EA) pretreatment at zusanli (ST36) acupoint on lipopolysaccharide (LPS)-induced endotoxemic rat model and explore the underlying molecular mechanisms. Rats were treated with EA at ST36 for 7 days before being subjected to LPS. Two hours post-LPS...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-018-0885-5
更新日期:2019-02-01 00:00:00
abstract::We investigated the molecular mechanisms underlying the role of miRNAs in the pathogenesis of psoriasis to discover novel potential diagnostic markers and treatment targets. We screened Chinese Han individuals using gene chip technology to identify differentially expressed miRNAs in the epidermal tissue of lesions fro...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-018-0859-7
更新日期:2018-12-01 00:00:00
abstract::Fasudil, a rock kinase inhibitor, can inhibit systemic inflammation and prevent paraquat (PQ)-induced acute lung injuries in rats; however, the mechanisms for these protective effects remain elusive. This study investigated how the Rho/ROCK signaling pathway enables fasudil to protect against acute lung injuries in PQ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-018-0860-1
更新日期:2018-12-01 00:00:00
abstract::Immune dysfunction contributes to secondary infection and worse outcomes in sepsis. Regulatory T cells (Tregs) have been implicated in sepsis-induced immunosuppression. Nevertheless, the role of Tregs in secondary infection after sepsis remains to be determined. In the present study, a two-hit model which mimics clini...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-018-0821-8
更新日期:2018-10-01 00:00:00
abstract::Corynoline, a bioactive compound isolated from Corydalis bungeana Turcz., has been known to have anti-inflammatory activity. However, its effects on the inflammation of the cardiovascular system have not been reported yet. The aim of this study was to investigate the anti-inflammatory effects of corynoline on lipopoly...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-018-0807-6
更新日期:2018-10-01 00:00:00
abstract::Chronic obstructive pulmonary disease (COPD), characterized by progressive airway inflammation and irreversible airflow limitation, leads to serious decline in life quality. The acute exacerbation of COPD (AECOPD) results in high healthcare costs as well as a significant mortality rate. The most common cause of acute ...
journal_title:Inflammation
pub_type: 杂志文章,评审
doi:10.1007/s10753-018-0830-7
更新日期:2018-10-01 00:00:00
abstract::Isoliquiritigenin (ILG), a major ingredient of licorice, has been reported to have anti-oxidative and anti-inflammatory effects. The aim of this study was to investigate the protective effects of ILG on lung injury using an animal model of lipopolysaccharide (LPS)-induced acute lung injury (ALI). Male BALB/c mice were...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-018-0777-8
更新日期:2018-08-01 00:00:00
abstract::Acute lung injury (ALI) is a serious disease with morbidity and mortality in patients. Engeletin (dihydrokaempferol 3-rhamnoside) is a flavanonol glycoside. It can be found in the skin of white grapes and white wine and is widely distributed in southeast Asia. In our study, we evaluated the protective and therapeutic ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-018-0773-z
更新日期:2018-08-01 00:00:00
abstract::The original version of this article contained mistakes, and the authors would like to correct them. ...
journal_title:Inflammation
pub_type: 杂志文章,已发布勘误
doi:10.1007/s10753-018-0770-2
更新日期:2018-06-01 00:00:00
abstract::Periodontitis has been advocated as a systematic chronic low-grade infection burden. However, the relationship between periodontitis and bone defect healing has not been elucidated. One hundred and eight male Wister rats were randomly assigned into three groups: control (healthy) group, periodontitis group, and period...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-018-0751-5
更新日期:2018-06-01 00:00:00
abstract::The excessive activation of microglia plays a key role in the pathogenesis of neurodegenerative diseases. The neuroprotective properties of rosmarinic acid have been reported in a variety of disease models both in vitro and in vivo; however, the mechanism underlying its anti-neuroinflammatory activity has not been cle...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-017-0728-9
更新日期:2018-03-01 00:00:00
abstract::The aim of this study is to investigate the cardioprotective effects of morroniside in rats following acute myocardial infarction. An acute myocardial infarction (AMI) was induced by ligating the anterior descending coronary artery (LAD) [1]. Following AMI, morroniside was administered intragastrically for 24 h at dos...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-017-0699-x
更新日期:2018-03-01 00:00:00
abstract::Osteoarthritis (OA) is a degenerative joint disease frequently seen in the elderly population. Sinapic acid (SA), a commonly found phenolic acid, has been pharmacologically evaluated for its anti-inflammation effects in various studies. To explore its potential therapeutic role for OA, rat chondrocytes were treated wi...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-017-0712-4
更新日期:2018-03-01 00:00:00
abstract::Shock is associated with inflammation-induced endothelial dysfunction. The aim of this study was to determine time-dependent alteration of blood biomarkers related to endothelial function in hemorrhagic and septic shocks. Hemorrhagic shock was induced by bleeding the animals. A cecal ligation and incision model was us...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-017-0660-z
更新日期:2018-02-01 00:00:00
abstract::The objective of this study is to investigate the role of Calmodulin-dependent protein kinase IV (CaMKIV) in Cardiotoxin (CTX)-induced mice muscle inflammation. CTX injection i.m. was performed to induce B6 mice acute tibialis anterior (TA) muscle injury. The mice were then injected i.p. with the recombinant CaMKIV pr...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-017-0678-2
更新日期:2018-02-01 00:00:00
abstract::Simvastatin, which is primarily prescribed to lower cholesterol, may also mitigate lung injury caused by sepsis, although the mechanisms remain elusive. This study aimed to evaluate the protective effect of simvastatin on acute lung injury in rats with sepsis and to investigate possible mechanisms. Male Wistar rats we...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-017-0668-4
更新日期:2018-02-01 00:00:00
abstract::Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by debilitating pain, cartilage destruction, and loss of joint function. Management of RA includes drugs that target NF-κB and downstream cytokine production. Therefore, molecules that act by inhibiting this signaling pathway without the severe si...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-017-0642-1
更新日期:2017-12-01 00:00:00
abstract::In this study, the potential effects of thalidomide (Thal) on bleomycin (BLM)-induced pulmonary fibrosis were investigated. BALB/C mice model of pulmonary fibrosis induced by an intratracheal instillation of BLM was adopted, and then was intraperitoneally injected with Thal (10, 20, 50 mg/kg) daily for 8 days, while t...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-017-0625-2
更新日期:2017-12-01 00:00:00
abstract::In the present study, we investigated the anti-inflammatory effect of roburic acid on production of nitric oxide (NO) and interlukin-6 (IL-6) in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. We found that roburic acid reduced production of NO and IL-6, and the expression of inducible nitric oxide synt...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-017-0636-z
更新日期:2017-12-01 00:00:00
abstract::Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease, in which pathogenesis is not clear. Many research demonstrated that fibroblast-like synoviocytes (FLSs) play a key role in RA pathogenesis, join in the cartilage injury and hyperplasia of the synovium, and contribute to the release of inflammatory...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-017-0591-8
更新日期:2017-10-01 00:00:00
abstract::Diabetic retinopathy (DR) is a serious-threatening complication of diabetes and urgently needed to be treated. Evidence has accumulated indicating that microglia inflammation within the retina plays a critical role in DR. Microglial matrix metalloproteinase 9 (MMP-9) has an important role in the destruction of the int...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-017-0571-z
更新日期:2017-10-01 00:00:00
abstract::Activated macrophages exhibiting diverse phenotypes and various functions contribute to the pathogenesis or amelioration of different diseases like cancer, inflammation, and infectious and autoimmune diseases. However, the mechanisms of macrophage polarization in inflamed joint and its effects on rheumatoid arthritis ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-017-0619-0
更新日期:2017-10-01 00:00:00
abstract::Inflammatory response is required to proceed the optimal liver regeneration after liver injury. Recent reports demonstrated that inflammasomes are involved in the innate immune response. Several NOD-Like receptors (NLRs) participated in the formation of the inflammasomes. NACHT, LRR, and PYD domain-containing protein ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-017-0613-6
更新日期:2017-10-01 00:00:00
abstract::Current treatments for ischemia-reperfusion (IR)-induced acute lung injury are limited. Mesenchymal stem cell-conditioned medium (CM) has been reported to attenuate lung injury. Neural crest stem cells (NCSCs), a type of multipotent stem cells, are more easily obtained than mesenchymal stem cells. We hypothesize that ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-017-0594-5
更新日期:2017-10-01 00:00:00
abstract::Postoperative ileus is a common complication after intra-abdominal surgery. Nitric oxide produced by macrophages in the inflamed gastrointestinal tract plays a crucial role in the pathogeny of postoperative ileus. Honokiol, extracted from the bark of Magnolia spp., is a natural compound with a biphenolic structure. In...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-017-0576-7
更新日期:2017-08-01 00:00:00
abstract::Statins are widely used hypocholesterolemic drugs that block the mevalonate pathway. Some studies have shown that statins may have the potential to inhibit intervertebral disk (IVD) degeneration (IDD). Interleukin (IL)-1β, a catabolic cytokine, is a key regulator of IDD. This study aimed to investigate the mechanism u...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-017-0516-6
更新日期:2017-06-01 00:00:00
abstract::Recent data demonstrated that chemokine CXCL13 mediates neuroinflammation and contributes to the maintenance of neuropathic pain after nerve injury in the spinal cord. Pro-nociceptive chemokines activate mitogen-activated protein kinases (MAPKs) which are potential signaling pathways contributing to the nociceptive be...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-017-0520-x
更新日期:2017-06-01 00:00:00
abstract::The present study was designed to investigate the effects of pilose antler peptide (PAP) on lipopolysaccharide (LPS)-induced lung injury. BalB/c mice intraperitoneally received PAP (10 and 20 mg/kg) or dexamethasone (2 mg/kg) 1 h prior to intratracheal instillation of LPS. PAP significantly decreased lung wet-to-dry w...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-017-0535-3
更新日期:2017-06-01 00:00:00
abstract::D-limonene epoxidation generates (+)-limonene epoxide, an understudied compound in the pharmacologically point of view. Herein, we investigated the anti-inflammatory and antinociceptive potentialities of (+)-limonene epoxide and suggested a mechanism of action. The anti-inflammatory potential was analyzed using agents...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-016-0496-y
更新日期:2017-04-01 00:00:00
abstract::Obesity provokes an imbalance in the immune system, including an aberrant type I interferon response during some viral infections and after TLR stimulation. SOCS3 overexpression and altered systemic leptin levels could be responsible for the reduced type I interferon production in people with obesity and, eventually, ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-016-0452-x
更新日期:2017-02-01 00:00:00
abstract::Polymorphonuclear neutrophils are among the first defense against infection and closely involved in the initiation of inflammatory response. It is well recognized that this function of neutrophils was mainly mediated by phagocytosis, intracellular degradation, releasing of granules, and formation of neutrophil extrace...
journal_title:Inflammation
pub_type: 杂志文章,评审
doi:10.1007/s10753-016-0458-4
更新日期:2017-02-01 00:00:00
abstract::Aberrant activation of the NOD-like receptor (NLR) family, pyrin domain-containing protein 3 (NLRP3) inflammasome, triggers a pathogenic inflammatory response in many inherited neurodegenerative disorders. Inflammation has recently been associated with valosin-containing protein (VCP)-associated diseases, caused by mi...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-016-0449-5
更新日期:2017-02-01 00:00:00